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SAEs were less common with oral semaglutide 14 mg (47.9%) than with placebo (50.3%), although there was a higher incidence of gastrointestinal disorders with oral semaglutide 14 mg (5.0% versus 4.4%)

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Nrf2 can bind to AREs on PINK1 promoter, and then upregulate PINK1 expression and promote mitophagy (Murata et al., 2015

Doctors can spot unusual symptoms with regular checkups

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Routine liver function monitoring is not required for patients without pre-existing liver disease, though baseline assessment may be appropriate in certain clinical situations