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doi: 10.1111/dom.14198 122 YangG-RZhaoX-LJinFShiL-HYangJ-K

and GCGR activation increases hepatic glucose output (balanced by incretin-mediated insulin), promotes energy expenditure through thermogenesis, and enhances hepatic fat oxidation

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The results were heterogeneous: some trials, such as AMPLITUDE-O and SELECT, demonstrated significant reductions in HF-related endpoints, whereas others, like LEADER, showed only non-significant favourable trends

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