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As obese humans show lower circulating glucagon-like peptide-1 (GLP-1), similar to that of PYY, it has been thought that the resistance to this gut hormone contributes to the obesity

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In fact, women on estrogen replacement may see a stronger GH response to the peptide protocol because estrogen enhances pituitary GH sensitivity, which means dosing may need to be adjusted accordingly

Denley A, Carroll JM, Brierley GV, Cosgrove L, Wallace J, Forbes B, Roberts CT

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