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Extreme weakness where you cannot perform basic daily activities goes beyond typical adjustment fatigue

Over time, this leads to reduced kidney function and can eventually cause kidney failure

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Pharmacology 15, 1415445

Severe fatigue can indicate medication intolerance or other medical issues requiring attention

By affecting all these cellular functions already impaired in aging individuals it could explain why older, comorbid patients have the most severe outcomes with COVID-19 (312) and stimulate the use of GSH and Nrf2 enhancers as well as develop new therapies to protect mitochondria