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Sun B, Luo C, Zhang X, Guo M, Sun M, Yu H, et al

*Although cosmetic surgery in men has been steadily increasing, male breast reduction surgery can still make some men feel self-conscious

Selection was based on the following criteria: five significant-risk impurities, defined by a high EpiMatrix Score/low JanusMatrix Score (increased epitope content, reduced human homology, considered likely to be immunogenic), and two low-risk impurities defined by a reduced EpiMatrix Score/higher JanusMatrix Score (low immunogenicity was expected)