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Across the subgroups of patients with different baseline cardiovascular conditions, mean age ranged from approximately 59 to 67 years, baseline BMI from 33.8 to 36.3 kg/m 2 , and baseline type 2 diabetes prevalence from 25.4% in aortic disease to 50.8% in heart failure, with broadly balanced matching across the individual subgroups (Table 2)

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When TOFO was added on top of PIO, the improvement of MRI-PDFF was insignificant (0.42%)

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Oral bioavailability and pharmacodynamic activity of Hesperetin nanocrystals generated using a novel bottom-up technology