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Novo Nordisk has filed at least 21 lawsuits nationwide against companies making purported copies of its drugs, accusing them of unlawful mass-producing and advertising "knockoffs." This legal pressure, combined with the FDA's intensified scrutiny, has already led to notable market shifts, such as Hims & Hers abruptly canceling its launch of a GLP-1 pill for weight loss shortly after the FDA's notice and Novo Nordisk's lawsuit

As a result, GLP-1RAs demonstrate a new therapeutic action in cirrhotic rats with cardiomyopathy through the protective role of HOTAIR via SIRT1 activation [86]

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