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This intricate interplay between metabolism, apoptosis, and fibrosis has been validated in single-cell sequencing studies, in which the spatiotemporal dialog between parenchymal and non-parenchymal cells constitutes the molecular basis of disease progression 54,55
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A leading compound in this class is GR-2397 (also known as ASP2397 or VL-2397), a cyclic hexapeptide developed by Gravitas Therapeutics (Nakamura et al., 2017
Semaglutide's known adverse effects include gastrointestinal symptoms (nausea, vomiting, constipation), pancreatitis risk, and thyroid concernsside effects that could theoretically be complicated by naltrexone's CNS effects
However, recent studies have revealed the potential for these compounds to also impact the pathological process of AD
It may also interact with nitric oxide pathways that affect blood vessels and inflammation
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