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Rousselle P, Braye F, Dayan G

Among the members of the caspase family, caspase-3 is a crucial modulator of apoptosis in mammalian cells [42]

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Thus, direct regulation of the gut microbiota can serve as one of the targets for regulating the production of TMAO

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J Neurol Sci 124:8487 Dupuis L, Dengler R, Heneka MT et al (2012) A randomized, double blind, placebo-controlled trial of pioglitazone in combination with riluzole in amyotrophic lateral sclerosis