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Nose to brain delivery of mirtazapine via lipid nanocapsules: Preparation, statistical optimization, radiolabeling, in vivo biodistribution and pharmacokinetic study

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Stacked Protocol (AOD + MOTS-c) Dose: 0.5 mg AOD + 10 mg MOTS-c (= 20 clicks) Duration: 4 weeks Frequency: Daily Cycle Interval: Optional 2-week pause Goal / Description: 2 weeks off, then repeat or switch to MOTS-c only maintenance Possible Side Effects AOD-9604 is generally well-tolerated in research settings

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