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4 Furthermore, SARS-CoV-2 infection has been shown to affect the CNS and cause a series of neuropsychiatric symptoms (eg, anosmia, headache, cognitive and attention deficits, disturbances in consciousness, anxiety, depression, delirium, and suicidal behavior) and diseases (eg, acute necrotizing encephalopathy, encephalitis, hypoxic brain injury, strokes, myelitis, tonic epilepsy, neurogenic respiratory failure, generalized myoclonus, and Kawasaki syndrome)

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10.1007/s11154-020-09546-9

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doi: 10.1053/j.gastro.2021.01.029 103 RodriguezJHielSNeyrinckAMLe RoyTPotgensSALeyrolleQet al

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Metabolomics 11 , 657666, (2015)

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High glucose status and insulin resistance in diabetic patients promote cell metabolism disorders and release a large amount of reactive oxygen species, which in turn activates nuclear factor B, induces the expression of inflammatory factors, damages vascular endothelial cells, and causes abnormal proliferation of smooth muscle cells

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