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Counterintuitively, mice completely defective for the GLP-1 receptor were reported to be protected from high-fat diet-induced peripheral Insulin resistance (177) and, consistently with this, central inhibition of GLP-1R signaling with the antagonist exendin 9-39 improves glucose tolerance and glycaemia (178)

Nature 635 , 9871000 (2024)

Koppenol WH, Bounds PL, Dang CV

& Ross, B