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Analysis of the tumors confirmed once more the enhanced expression of SHMT2 in irradiated tumors compared to non-irradiated tumors, verifying their need for ser/gly pathway metabolites in response to irradiation (Fig

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We show that the PPP generates NAPDH to support GSSG recycling, which facilitates oxidative protein folding, sustains ER proteostasis and prevents ferroptosis during chondrocyte differentiation

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