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However, if a person bleeds enough to cause hypovolemia, this requires prompt treatment with intravenous fluids.

Acknowledgments We would like to thank Clara Marin Briggiler for her insightful comments, and Nria Correa Maas for her contribution with statistical analyses

Additional questions include how to mitigate lean muscle mass loss, which is important for joint stability, and whether adding glucose-dependent insulinotropic polypeptide or glucagon receptor activation could offer advantages over GLP-1 agonists on their own

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Side-effect management anti-nausea medication, electrolyte support, and the occasional dose-pause week add small recurring costs

"It would be a wearable patch system, probably replaced on a daily basis