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223,224 Recent research indicates that DNA methylation is possible on cytosine and adenine bases, including 5-methylcytosine (5mC), N 6 -methyladenine (6mA), and N 4 -methylcytosine (4mC)

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Serious but less common adverse effects include pancreatitis, gallbladder disease, acute kidney injury (particularly in the setting of dehydration from gastrointestinal symptoms), and hypoglycemia when used in combination with insulin or sulfonylureas

This stepwise escalation allows researchers to identify the minimum effective dose for each subject

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