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Researchers studying pulsatile GH kinetics may select the shorter-acting compounds to model physiological pulse patterns, while those studying downstream IGF-1 effects may favour ipamorelin's extended peak to ensure adequate GH receptor engagement duration

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Pathophysiology of IrAEs Several immunopathogenic mechanisms (i.e., cellular autoimmunity, autoantibodies, complement activation, cytokines/chemokines release, genetics and alterations of the gut microbiome) have been suggested to be involved in the development of ICI-related irAEs ( Figure 2 )

Arch Dermatol Res 304:499510

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