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It is advisable to consider switching to a non-oral contraceptive method or to use additional protection for four weeks after starting tirzepatide or increasing its dose

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Similarly, niacinamide concentrations should not exceed 10% for periorbital use versus 15-20% sometimes used on face, and retinoids if included should be present only in gentle forms at low concentrations to avoid significant irritation

Acknowledgements This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (the Ministry of Science & ICT, MSIT) (RS-2024-00350878 and RS-2023-00242443), and by the Korean Fund for Regenerative Medicine (KFRM) funded by MSIT and the Ministry of Health and Welfare, Republic of Korea (RS-2025-02223118)

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