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Rather, it causes the production of melanin to include pigments of lower pigmentation that persist and decrease excess pigmentation progressively

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Similar results, including elevated ROS, Fe 2+ and GPX4 levels, were observed in IMR90 cells undergoing etoposide-induced senescence (Extended Data Fig

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Abbreviations ALI: Acute Lung Injury ECM: Extracellular Matrix FN1: Fibronectin 1 GSH: Glutathione H&E: Hematoxylin and Eosin Hg: Mercury HIF1: Hypoxia-Inducible Factor 1 MDA: Malondialdehyde MMP: Matrix Metalloproteinase MPO: Myeloperoxidase NAC: N-Acetylcysteine NO: Nitric Oxide NOS: Nitric Oxide Synthase qRT-PCR: Quantitative Real-Time Polymerase Chain Reaction ROS: Reactive Oxygen Species SOD: Superoxide Dismutase TIMP: Tissue Inhibitor of Metalloproteinases References Da Silva RF, Borges Cdos S, Villela ESP, Missassi G, Kiguti LR, Pupo AS, Barbosa Junior F, Anselmo-Franci JA, Kempinas Wde G