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Caution all patients that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure, with the same consequences of lightheadedness and possible syncope [see Warnings and Precautions (5.2)]

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Discussion Our cryo-EM and functional analyses indicate that the concurrent binding of one HGF to two c-METs by utilizing two completely distinct interfaces leads to c-MET dimerization and activation

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