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After the initial introduction of SGLT2i in 2013 [9] and following demonstration of kidney and cardiovascular outcome benefits for patients with type 2 diabetes, in 2021 the US Food and Drug Administration (FDA) provided the first indication that SGLT2i reduced the risk of kidney disease progression in patients with CKD [10, 11]

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Anyone reviewing a product page for Ozempic or Rybelsus should keep in mind that individual interaction risk varies by health history, so a providers review remains an important step before starting treatment

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They're appropriate for specific medical conditions and require medical supervision

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Who Should Avoid Semaglutide: Contraindications and Risk Groups Semaglutide carries absolute contraindications for patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 syndrome, as animal studies suggested potential thyroid c-cell proliferation, though no human cases have been documented

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