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In January 2025 , a narrative review in Cureus evaluated the efficacy and safety of oral, topical, and intravenous glutathione for skin lightening

These metabolic pathways, rather than a direct anti-proliferative action, may be the target as Metformin decreases hepatic gluconeogenesis, improves insulin sensitivity, reduces insulin and blood glucose levels, and these effects, which also will reduce tumor growth, rather than a direct anti-proliferative action may be the primary target of metformin (248)

Some providers recommend thyroid function and liver/kidney screening

The slowing simply reflects approaching your bodys defended lower weight range