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In addition to the US FDA approved GLP-1RAs, there are GLP1/glucagon dual agonists (Cotadutide, BI 456906), GIP/GLP1 dual agonists (Tirzepatide, GIP/GLP peptide I and II), GIP/GLP1/glucagon tri-agonists (HM15211, GGG tri-agonist) and GLP1R agonists (Efpeglenatide, Rybelsus) currently in phase 1- III clinical trials for T2D, obesity, and NASH (MASH) treatments (12)

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When paired with structured support like personalized meal plans and regular check-ins, these medications become powerful tools in a holistic health program

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Conversely, the 1-5 mg range is increasingly gaining traction, reflecting a surge in demand for tailored dosing to meet diverse patient needs and enhance therapeutic efficacy