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How can we measure progress if we don't even know the baseline

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"It is yo-yo dieting on crack." (Responding to a 2022 study that showed patients regain the weight, Novo Nordisk, the makers of Ozempic and Wegovy, said in a statement, "Not unexpectedly, patients experience weight regain once they stop taking the medication

The LEADER trial demonstrated cardiovascular benefits with liraglutide while other large outcome studies show GLP 1 medications improve endothelial function, reduce blood pressure modestly and favorably modify inflammatory and lipid markers

However, the reported sensitivity and specificity of such findings are quite variableranging from less than 20% to over 90% [27,28,29]

The mechanisms underlying epileptic pathogenesis and neuronal death remain unclear