This study is to explore a GSH-responsive AP probe-net, which can be activated by the abundant GSH in ATC cells to generate reactive alkoxyamine, and the formed alkoxyamine can trap AP sites and block the APE1 activity, leading to ATC cell death but less adverse effects towards normal cells
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Human pharmacokinetics, safe dosing, and long-term effects are entirely uncharacterized
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McMillin, D
Iranmanesh, A., Lizarralde, G