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PMID 21593213

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Amino acids V12 (putative oxyanion hole), F112 (active site architecture), N108 (flavonoid binding) and C13 (GSH stabilization) were fully randomized by site saturation mutagenesis (NNK codons), and the created Pt GSTF8 variants were tested for conversion of flavan-3,3,4-triol ( 4 ) to cyanidin ( 8 ), and for their GSH-transferase activity towards CDNB ( 5 ) as a control of catalytic competence

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Iotti et al., 2020) and could not only prevent SARS CoV-2 infection, reduce severity of COVID-19 symptoms and facilitate disease recovery (Trapani et al., 2022) but benefit enzymatic activity of the GSH pathway in COVID-19