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The GHRH receptor population on somatotrophs appears to saturate near 2 mg, after which further dose increases no longer proportionally increase GH pulse amplitude

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Thioxanthines such as flupentixol and phenothiazines like fluphenazine also demonstrate this strong affinity

The conserved disulfide bridgeanalogous to Cys182Cys189 in full-length hGHpotentially confers structural stability by locking the peptide into a bioactive conformation

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