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It remains a research compound in most jurisdictions, available for purchase as a research chemical but not as a regulated medication

If breakouts appear in unusual areas or persist beyond six weeks, discontinue use and consult a dermatologist

It was named so because it was first discovered in the gall of a bull

doi: 10.3389/fphar.2025.1660890 Received 08 July 2025 Accepted 04 September 2025 Published 01 October 2025 Volume 16 - 2025 Edited by Sarmistha Saha, GLA University, India Reviewed by Sidharth Mehan, Indo-Soviet Friendship College of Pharmacy, India Pratibha Singh, All India Institute of Medical Sciences, India Updates Copyright 2025 Peng, Meng, Deng, Huang, Mao, Long, Yan, Peng, Wang and Liu

It converts melanin from its darker form (eumelanin) to a lighter form (pheomelanin), resulting in a lighter skin tone over time

Combination with an SGLT2-i is subsidised only after step-wise criteria (not for initial therapy)