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Safety considerations for -adrenergic receptor modulators -Blockers remain cornerstone therapies for portal hypertension and cardiac protection in cirrhosis

Oral bioavailability, which is the measure of drug exposure in systemic circulation following oral dosing compared against IV dosing using AUC calculation, is critical to understanding if low systemic concentration comes from either poor absorption, first pass metabolism, or both ( in vivo stability

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Additionally, the translational relevance of these findings likely differs by disease phenotype