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Recovery and Gastrointestinal Function Ipamorelin demonstrates significant prokinetic effects on gastrointestinal motility, particularly in accelerating recovery from postoperative ileus (POI), a common complication following abdominal surgery characterized by transient loss of gastrointestinal motility

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This is one reason the safety and side effect profile of GH secretagogues tends to be more favourable than that of exogenous HGH, particularly regarding IGF-1 overshoot and glucose dysregulation