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These two approaches don't have to be viewed as competing strategies

Although amino acid substitution is an effective strategy to reduce proteolytic degradation, modified GLP-1 analogs are still subject to rapid renal clearance, making it difficult to further prolong peptide circulation time

[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Noctor G, Queval G, Mhamdi A, Chaouch S, Foyer CH

It is manufactured as BPC-157 (Pentadecapeptide) 5mg/vial injection containing Pentadecapeptide 5mg and excipients

Often studied in combination with other GHRHs (like CJC-1295)