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Horn and his team have received numerous accolades and awards for their outstanding contributions to the field of medical weight loss

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Very recently, another anterograde tracing study in the mouse corroborated our own observations by demonstrating the close proximity of vagal afferents to intestinal enterochromaffin cells, without establishing direct contacts 44

As the unconventional XBP1 mRNA splicing by IRE1 and the subsequent activation of the spliced XBP1 protein expression are the major mechanism of ER homeostasis regulation by IRE1 10 , we tested whether XBP1 plays a role in IRE1-mediated ferroptosis sensitization

Therefore, modulating autophagy may offer a novel intervention strategy for improving DOR