In an earlier study, we showed, using an immunocompetent mouse model of endometriosis, generated with intraperitoneal administration ( ip ) of endometrial fragments null for the progesterone receptor interacting protein Krppel-like Factor 9 (KLF9), that high-fat diet (HFD) promoted endometriosis progression in the absence of ovarian dysfunction, insulin resistance, and significant increase in bodyweight (Heard et al., 2016)
No, outcomes are not irreversible
doi: 10.1073/pnas.1522193112 42 ZhaoQColeTZhangYTangS-Y
doi: 10.3390/jcm11206102 117 JelicMDMandicADMaricicSMSrdjenovicBU
Shiraki M, Shimizu M, Moriwaki H, et al
The lumbar spine BMD increased by 8% and hip BMD increased by 6% in the weight loss+AOD 9604 group (reversing bone loss and net growth)