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Diabetes Ther (2018) 9(2):789801

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Contact your GP or diabetes care team within 2448 hours if you experience recurrent episodes of light-headedness (more than 23 times weekly), symptoms lasting longer than 1015 minutes, light-headedness severe enough to cause falls or near-falls, persistent symptoms despite implementing self-management strategies, or if light-headedness is significantly impacting daily activities or quality of life

it's a direct statement about how the asynchronous model depends on what you report

Understanding that this is a pharmacokinetic artifact, not a sign that the medication has stopped working, helps manage expectations

It is also much more affordable than metreleptin