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Because th information on these drug side effects has been obtained from voluntary reports from a total patient population of uncertain size, the precise frequency of events, and whether a causal relationship exists, remains unclear

Existing extended-release options, like weekly formulations of semaglutide and dulaglutide, have reduced injection frequency, and future innovations may include monthly formulations or implantable devices that deliver continuous therapy

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Certain medications can contribute to leg cramps, including loop and thiazide diuretics, beta-agonists, and statins (which more commonly cause diffuse myalgia rather than focal cramps)

For symptom relief, both traditional antacids (containing calcium carbonate, magnesium compounds) and alginate-based products (which form a protective layer on top of stomach contents) may be helpful options