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It's my biggest fear in life," she said

This tells us these drugs should be seen as a long-term commitment. If patients regain weight after stopping, as clinicians and studies suggest, the commercial logic sharpens: these treatments are most effective, and most valuable, when they are sustained over time

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Xicoy H, Wieringa B, Martens GJM

d , A 100 nM SR101 solution was applied to an intact mouse skull for 30 min, then immediately thinned and imaged while the skull was submerged in aCSF to determine the decay in the meningeal SR101 concentration over time