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PXR increases two enzymes (CYP24, CYP3A4) that break down 1,25 D 3 /Calcitriol, the active form of vitamin D in humans [1]

Dolotov, O.V., Karpenko, E.A., Inozemtseva, L.S., Seredenina, T.S., Levitskaya, N.G., Rozyczka, J., & Grivennikov, I.A

Disruption of any of these axes, including iron overload, PUFA enrichment, cysteine depletion, or selenium deficiency, can shift the cellular balance towards ferroptotic collapse

Cancer Res 54 : 22182222 Resnicoff M, Tjuvajev J, Rotman HL, Abraham D, Curtis M, Aiken R, Baserga R (1996) Regression of C6 rat brain tumors by cells expressing an antisense insulin-like growth factor I receptor RNA

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