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Epitalon has been characterized across a substantial body of peer-reviewed research, primarily conducted in cell culture systems and rodent models, examining telomere biology, neuroendocrine regulation, antioxidant signaling, and epigenetic modulation within the context of cellular aging research

Specifically, it was theorized that NO inhibits ryanodine receptors, thereby decreasing calcium release and subsequent cross-bridge formation (Reid, 1998

Trickler D, Shklar G, Schwartz J