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Important caveat: TRIUMPH-4 enrolled participants with obesity plus knee osteoarthritis, not a general obesity population

To reduce flexibility to favour crystallization, a disulfide bond was introduced in a flexible loop connecting the -sheet segment to the two -helices of CYTX, yielding a candidate (CYTX_B10) with improved thermal stability ( T m = 70.3 C) and monomeric profile during SEC, but a slightly weaker K d of 740 nM for N

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