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New Trial Results STEP-HFpEF DM published in NEJM today Semaglutide improved heart failure symptoms and physical limitations in patients with obesity, HFpEF and Type 2 Diabetes 6.4% weight over placebo CRP 6 min walk distance These results are consistent with findings of a prior trial of semaglutide in HFpEF and obesity without type 2 diabetes

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Many patients find that gastrointestinal side effects tend to improve as their body adjusts to a stable dose