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Chronic insuffi ciency can affect the spinal cord, peripheral nerves, optic nerve, and brain

A key difference may be the timing of muscle sampling as it is unclear when dissection of the mice was performed relative to the last BA dose ( Muscle carnosine loading is most pronounced during the initial weeks of supplementation, after which increases in muscle carnosine content appear to slow

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Current research indicates that systemic absorption of unmodified peptides is generally lower and less predictable when administered orally