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Body composition data from the SURMOUNT-1 DXA substudy showed approximately 75% of weight lost came from fat mass and 25% from lean mass

Malnutrition, fasting and vegetarianism Reduced plasma carnitine levels have been noted in malnourished children [106] and adults [107]

That mix of motivations matters for insurers because public drug plans generally only cover GLP1s for type 2 diabetes, leaving most obesityfocused use in the private market, the survey said

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The post-prandial GLP-1 and PYY response is reported to be blunted in obese patients (116)

To overcome these limitations, future studies should focus on refining organoid coculture systems, integrating tumor-immune components, and developing short-term dynamic models that preserve cellular heterogeneity and better simulate in vivo conditions