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Datos toxicolgicos preclnicos: Los estudios de toxicidad aguda y subaguda en la rata no han evidenciado mortalidad ni toxicidad orgnica significativa, incluso a dosis ampliamente superiores a las dosis teraputicas (hasta 100 veces la dosis eficaz)

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Based on such evolving biology, the 3Ts protocol integrates all available therapeutic tools, pharmacologic oxygenation (tadalafil), intralesional biologic regeneration (tunneling), and mechanical remodeling (traction) to promote true tissue restoration rather than simple deformity correction (Table 1)