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2023 Apr 27;16:1123-1134

Treatment of HCC cells with ADI-PEG20 downregulates the key enzymes of pyrimidine synthesis in the TCA cycle, carbamoyl phosphate synthetase 2, thymine synthase (TS), aspartate transcarbamylase and dihydrooratase (CAD) and malate dehydrogenase 1 (MDH-1) activities, making tumor cells more susceptible to 5-fluorouracil (5-FU)

The clinical course was variable with some patients having slower progression of neurological manifestations [90,91,103]

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patients who commit to a multi-session protocol and combine it with disciplined sun protection and a thoughtful topical regimen see real results