Semaglutide works by reducing appetite and delaying food absorption, leaving you feeling fuller for longer and less hungry throughout the day
However, if you were on a high dose of tirzepatide, even 3% of a 15mg dose means roughly 0.45mg of active compound still circulating
The timeline for side effect improvement is comparable
A patient who tolerates the medication and stays on it for a year will lose more weight than a patient who escalates quickly and quits at month three because of intolerable side effects
Brian Wojeck, an obesity medicine specialist at the Yale School of Medicine, likened it to what happens after bariatric surgery, in which patients often experience temporary shedding due to stress and rapid metabolic change
p = 0.0009), reflecting an 87% decrease in risk