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Given that CDK5 and GSK-3 are strong tau kinases [50], this vicious cycle induced by palmitoyl-L-carnitine may result in a feedback loop of mitochondrial dysfunction and tau hyperphosphorylation, exacerbating AD pathology

Purified MDH (~1 mL) was dialyzed for 4 h in 1 L buffer 2 (20 mM MOPS-KOH pH 7.5, 150 mM NaCl) containing 10 mM EDTA followed by three times dialysis against 1 L of buffer 2

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The side effects were so bad she was vomiting multiple times a week, and she still didnt want to stop