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However, frail elderly patients and those over 80 years are often underrepresented in clinical trials, meaning real-world clinical judgement is paramount

doi: 10.1016/j.gtc.2020.10.005 72 CollinsFVarmusH

[DOI] [Google Scholar] 64.Prior R.L., Cao G

In May 2026, Lilly reported that its pivotal Phase 3 TRIUMPH-1 trial gave an average weight loss of about 28% to 30% on the top dose

In December 2025, this breakthrough technology expanded to weight management when the FDA approved the Wegovy pill the first oral GLP-1 medication specifically for obesity and weight loss