In REDEFINE 1, adverse events were mainly gastrointestinal (79.6% in the CagriSema group vs 39.9% with placebo) including nausea (55% vs 12.6%), constipation (30.7% vs 11.6%), and vomiting (26.1% vs 4.1%)
doi: 10.3389/fnagi.2015.00213
For subcutaneous injection, you want the needle to reach the fat layer beneath the skin without penetrating into the muscle below
In 2024, Blue Cross Blue Shield of Michigan, the states largest nonprofit insurer, and North Carolina's state employee public insurance agency stopped covering the drugs for weight loss, saying the cost increased premiums for all customers
This means that the higher the dose, the more severe the side effects usually are
A single pharmacy info sheet covered injection technique and storage