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For example, in the SURMOUNT-4 trial, participants who continued tirzepatide treatment experienced further weight reduction, while those who switched to a placebo saw weight regain

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EVIDENCE GRADES Each component has independent peer-reviewed literature

Two drugmakers are now offering a new generation of these GLP-1 drugs, whose effects on weight loss have been spectacular

The risk of hypoglycemia increases during periods of reduced food intake

For women, the primary interest lies in its influence on melatonin secretion and circadian function both of which decline markedly in menopause and contribute to the sleep disruption that compounds metabolic deterioration in this phase