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Despite these encouraging mechanistic and preclinical findings, the KD should be viewed strictly as an adjunctive, not curative, strategy

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The extrinsic pathway involves the activation of a protease cascade intitated by the activation of caspase 8 through the action of death receptors and their ligands, for example, FasL, and tumor necrosis factor- (181)

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The crystal structure of human membrane-bound dipeptidase has been reported [49]

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