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In healthy men, no harm was found

Notably, the observed variability in efficacy between agents, particularly in the early phases of treatment, emphasizes the importance of individualized therapeutic strategies, tailored to specific clinical goals, baseline metabolic profiles, and patient preferences

As additional data accrue, future analyses should examine persistence, switching over time, and clinical outcomes associated with oral semaglutide use

But because people on semaglutide or tirzepatide lose more weight in the first place, they all end up returning to baseline at approximately the same time, study senior researcher Dimitrios Koutoukidis of Oxford University told Reuters

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And the uncomfortable question at the center of it all became impossible to ignore: who should pay for the most popular class of drugs in modern medicine